The Use of Atomic Force Microscopy in Comprehensive Assessment of the "Mother-Placenta-Fetus" System in Obstetric and Endocrine Pathology during Pregnancy

Bull Exp Biol Med. 2021 May;171(2):254-257. doi: 10.1007/s10517-021-05206-3. Epub 2021 Jun 26.

Abstract

Atomic force microscopy is not very popular in practical health care, therefore, its potential is not studied enough, for example, in obstetrics when studying the "mother-placenta-fetus" system. Our study summarizes the possibilities of using atomic force microscopy for detection of various circulatory disorders and vascular changes at the microscopic level in the uterus (endometrium and myometrium), placenta, and umbilical cord in the main variants of obstetric and endocrine pathology. For instance, in the case of endocrine pathologies, changes in the form of stasis, sludge, diapedesis, ischemia, destruction and separation of endotheliocytes in villous blood vessels were found in the mother. The oxygen content in erythrocytes also naturally decreased in pathologies; poikilo- and anisocytosis were observed.

Keywords: obstetrics; placenta; scanning microscopy; uterus.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Case-Control Studies
  • Chorionic Villi / blood supply
  • Chorionic Villi / diagnostic imaging
  • Chorionic Villi / pathology
  • Chorionic Villi / ultrastructure
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / diagnostic imaging
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diagnosis
  • Diabetes, Gestational / diagnostic imaging
  • Diabetes, Gestational / pathology
  • Female
  • Fetus / blood supply
  • Fetus / diagnostic imaging
  • Hematologic Tests / methods
  • Humans
  • Maternal-Fetal Relations
  • Microscopy, Atomic Force*
  • Microscopy, Electron, Scanning
  • Myometrium / diagnostic imaging
  • Myometrium / pathology
  • Myometrium / ultrastructure
  • Placenta / blood supply
  • Placenta / diagnostic imaging
  • Placenta / pathology
  • Placenta / ultrastructure
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / diagnosis
  • Pre-Eclampsia / diagnostic imaging
  • Pre-Eclampsia / pathology
  • Pregnancy
  • Pregnancy Complications / blood
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / diagnostic imaging
  • Pregnancy Complications / pathology
  • Pregnancy in Diabetics / blood
  • Pregnancy in Diabetics / diagnosis
  • Pregnancy in Diabetics / diagnostic imaging
  • Pregnancy in Diabetics / pathology
  • Prenatal Diagnosis / methods*
  • Thyroid Diseases / blood
  • Thyroid Diseases / diagnosis
  • Thyroid Diseases / diagnostic imaging
  • Thyroid Diseases / pathology
  • Umbilical Cord / blood supply
  • Umbilical Cord / diagnostic imaging
  • Umbilical Cord / ultrastructure
  • Uterus / blood supply
  • Uterus / diagnostic imaging
  • Uterus / ultrastructure