Novel cholecystokinin antagonists from Aspergillus alliaceus. I. Fermentation, isolation, and biological properties

M A Goetz; R L Monaghan; R S Chang; J Ondeyka; T B Chen; V J Lotti

doi:10.7164/antibiotics.41.875

Novel cholecystokinin antagonists from Aspergillus alliaceus. I. Fermentation, isolation, and biological properties

J Antibiot (Tokyo). 1988 Jul;41(7):875-7. doi: 10.7164/antibiotics.41.875.

Authors

M A Goetz¹, R L Monaghan, R S Chang, J Ondeyka, T B Chen, V J Lotti

Affiliation

¹ Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.

PMID: 3417561
DOI: 10.7164/antibiotics.41.875

Abstract

The discovery and biological properties of four novel cholecystokinin antagonists produced by Aspergillus alliaceus is described. One of these was seven times more potent than the previously reported asperlicin.

MeSH terms

Animals
Aspergillus / metabolism*
Benzodiazepinones / biosynthesis
Benzodiazepinones / isolation & purification*
Benzodiazepinones / pharmacology
Cholecystokinin / antagonists & inhibitors*
Fermentation*
Rats

Substances

Benzodiazepinones
Cholecystokinin
asperlicin