The heterogeneity of Epithelioid Hemangioendothelioma (EHE): A case series and review of the literature with emphasis on treatment options

Stijn Witte; Marije Weidema; Suzanne Kaal; Yvonne Versleijen-Jonkers; Uta Flucke; Winette van der Graaf; Ingrid Desar

doi:10.1053/j.seminoncol.2021.04.002

The heterogeneity of Epithelioid Hemangioendothelioma (EHE): A case series and review of the literature with emphasis on treatment options

Semin Oncol. 2021 Apr;48(2):111-118. doi: 10.1053/j.seminoncol.2021.04.002. Epub 2021 Jun 1.

Authors

Stijn Witte¹, Marije Weidema¹, Suzanne Kaal¹, Yvonne Versleijen-Jonkers¹, Uta Flucke¹, Winette van der Graaf¹, Ingrid Desar²

Affiliations

¹ Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.
² Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: [email protected].

PMID: 34176654
DOI: 10.1053/j.seminoncol.2021.04.002

Abstract

Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular sarcoma with a very heterogeneous presentation and prognosis. We here present five cases of EHE emphasizing diversity in presentation, treatment, and prognosis. Furthermore, we present a review of the literature on EHE treatment options.

Keywords: Epithelioid Hemangioendothelioma; Heterogeneity; Systemic treatment.

Publication types

Review

MeSH terms

Adult
Child
Hemangioendothelioma, Epithelioid* / genetics
Hemangioendothelioma, Epithelioid* / therapy
Humans
Prognosis
Sarcoma*