Asynchronous synaptic responses in hippocampal CA1 neurons during synaptic long-term potentiation

S S Chirwa; B R Sastry

doi:10.1016/0304-3940(88)90552-6

Asynchronous synaptic responses in hippocampal CA1 neurons during synaptic long-term potentiation

Neurosci Lett. 1988 Jul 8;89(3):355-60. doi: 10.1016/0304-3940(88)90552-6.

Authors

S S Chirwa¹, B R Sastry

Affiliation

¹ Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

PMID: 3419633
DOI: 10.1016/0304-3940(88)90552-6

Abstract

In guinea pig hippocampal slices incubated in Ba2+, stimulation of stratum radiatum induced an EPSP that was followed by an increased frequency of miniature EPSPs in CA1 neurons. These miniature EPSPS, which were presumably due to the asynchronous release of transmitter, were increased after the induction of long-term potentiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Barium / pharmacology
Electric Stimulation
Electrophysiology
Hippocampus / cytology
Hippocampus / physiology*
In Vitro Techniques
Motor Endplate / physiology
Neuromuscular Junction / physiology
Neurons / physiology*
Picrotoxin / pharmacology
Synapses / physiology*

Substances

Picrotoxin
Barium