The influence of colonic stenosis resulting in faecal loading was investigated in regard to collagen metabolism in the intact colonic wall. The collagen content was increased in the left colon proximal to the stenosis, due to enhanced collagen synthesis. The collagen concentration fell significantly, however, as noncollagenous substances increased more than collagen. Collagen concentration clearly can be misleading as an indication of the actual amount of collagen. The enhanced rate of collagen turnover with collagen accumulation proximal to stenosis requires further analysis in regard to its importance for healing capacity.