Use of freeze-dried trivalent antivenom to neutralize the toxic activities of Bothrops atrox snake venoms from the Amazon

Toxicon. 2021 Sep:200:19-22. doi: 10.1016/j.toxicon.2021.06.015. Epub 2021 Jun 29.

Abstract

In Brazil, antivenom for snakebite is currently formulated in liquid form and requires storage at 4 °C. Here, a new freeze-dried trivalent antivenom, which would enable cold-chain free storage, was determined to have efficacy in neutralizing the biological activities of Bothrops atrox venoms from Manaus (Brazil) and Leticia (Colombia), exhibiting an efficacy similar to those of currently available liquid Bothrops antivenoms. These results indicate that freeze-dried trivalent antivenom may be beneficial for applications in the Brazilian and Colombian Amazon regions.

Keywords: Amazon; Bothrops atrox snake venom; Freeze-dried antivenom; Liquid antivenom.

MeSH terms

  • Animals
  • Antivenins
  • Bothrops*
  • Crotalid Venoms* / toxicity
  • Snake Bites*
  • Snakes

Substances

  • Antivenins
  • Crotalid Venoms