Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

Ming Yang; Xi Wang; Yachun Han; Chenrui Li; Ling Wei; Jinfei Yang; Wei Chen; Xuejing Zhu; Lin Sun

doi:10.2174/0929867328666210705153109

Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

Curr Med Chem. 2021;28(42):8810-8824. doi: 10.2174/0929867328666210705153109.

Authors

Ming Yang¹, Xi Wang², Yachun Han¹, Chenrui Li¹, Ling Wei¹, Jinfei Yang¹, Wei Chen¹, Xuejing Zhu¹, Lin Sun¹

Affiliations

¹ Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
² Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China.

PMID: 34225600
DOI: 10.2174/0929867328666210705153109

Abstract

Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As the most deeply studied inflammasome, NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression. In this review, we summarize our understanding of the structural composition and activation factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3 inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic target for DN will also be discussed.

Keywords: DN progression.; NLRP3 inflammasome; diabetic nephropathy (DN); end-stage renal disease (ESRD); inflammation; structure of the NLRP3.

Publication types

Review

MeSH terms

Diabetes Mellitus*
Diabetic Nephropathies* / drug therapy
Humans
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Substances

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding