Single-stage long-segment tracheal transplantation

Am J Transplant. 2021 Oct;21(10):3421-3427. doi: 10.1111/ajt.16752. Epub 2021 Jul 19.

Abstract

Tracheal transplantation has been envisioned as a viable option for reconstruction of long-segment tracheal defects. We report the first human single-stage long-segment tracheal transplantation. Narrow-band imaging and bronchoscopic biopsies demonstrate allograft vascularization and viable epithelial lining. The recipient was immunosuppressed with Tacrolimus, Mycophenolate mofetil, and corticosteroids. Six months after transplantation, the trachea is both functional and the patient is breathing without the need of a tracheostomy or stent.

Keywords: clinical research/practice; organ procurement; surgical technique; vascularized composite and reconstructive transplantation.

MeSH terms

  • Humans
  • Mycophenolic Acid
  • Plastic Surgery Procedures*
  • Trachea* / diagnostic imaging
  • Trachea* / surgery
  • Transplantation, Heterotopic
  • Transplantation, Homologous

Substances

  • Mycophenolic Acid