DRD3-dependent plasticity within the VP drives subcircuit activity critical for cocaine seeking

Rianne R Campbell; Mary Kay Lobo

doi:10.1016/j.neuron.2021.06.011

DRD3-dependent plasticity within the VP drives subcircuit activity critical for cocaine seeking

Neuron. 2021 Jul 7;109(13):2043-2044. doi: 10.1016/j.neuron.2021.06.011.

Authors

Rianne R Campbell¹, Mary Kay Lobo²

Affiliations

¹ Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
² Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: [email protected].

PMID: 34237276
DOI: 10.1016/j.neuron.2021.06.011

Abstract

The ventral pallidum (VP) is a key hub within the reward system that mediates drug-seeking behaviors. However, molecular and cellular adaptations within the VP following drug use are not fully elucidated. In this issue of Neuron, Pribiag et al. (2021) demonstrate how cocaine induces circuit-specific changes within the VP via dopamine-receptor-D3-dependent processes to promote cocaine seeking.

Publication types

Comment

MeSH terms

Basal Forebrain*
Cocaine*
Drug-Seeking Behavior
Neurons
Reward

Substances

Cocaine