PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca2+ Content

Circ Res. 2021 Sep 3;129(6):650-665. doi: 10.1161/CIRCRESAHA.121.318473. Epub 2021 Jul 12.

Abstract

[Figure: see text].

Keywords: calcium; long QT syndrome; sildenafil citrate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Signaling*
  • Carbazoles / therapeutic use
  • Cyclic Nucleotide Phosphodiesterases, Type 5 / metabolism
  • Female
  • Long QT Syndrome / drug therapy*
  • Long QT Syndrome / etiology
  • Long QT Syndrome / metabolism
  • Phenethylamines / toxicity
  • Phosphodiesterase 5 Inhibitors / pharmacology
  • Phosphodiesterase 5 Inhibitors / therapeutic use*
  • Potassium Channel Blockers / toxicity
  • Protein Kinase Inhibitors / therapeutic use
  • Protein Kinases / metabolism
  • Sarcoplasmic Reticulum / drug effects
  • Sarcoplasmic Reticulum / metabolism*
  • Sheep
  • Sildenafil Citrate / pharmacology
  • Sildenafil Citrate / therapeutic use*
  • Sodium / metabolism
  • Sulfonamides / toxicity

Substances

  • Carbazoles
  • Phenethylamines
  • Phosphodiesterase 5 Inhibitors
  • Potassium Channel Blockers
  • Protein Kinase Inhibitors
  • Sulfonamides
  • KT 5823
  • Sodium
  • Sildenafil Citrate
  • Protein Kinases
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • dofetilide
  • Calcium