The method of dental implantation in patients with generalized periodontitis is one of the priority areas requiring in-depth study. The aim of the study was to increase the efficiency of dental implantation in prosthetic rehabilitation of patients with generalized periodontitis. A study of 240 patients with chronic generalized periodontitis and partial edentulous upper and lower jaw was carried out, who subsequently underwent complex periodontal treatment and dental implantation. The patients were divided into groups depending on the severity of generalized periodontitis (I, II, III) and the method of treatment. Evaluation of the results of the effectiveness of the proposed method of surgical treatment of patients with generalized periodontitis of the first stage of development with one-stage and staged dental implantation and targeted osteotropic therapy showed that after 12 months all implants (100%) were preserved. In patients with grade II generalized periodontitis, who underwent periodontal treatment and dental implantation in stages, the safety of implants was 92.1%, and in patients who underwent one-stage dental implantation with surgical treatment of periodontal disease, the safety of implants was 89,4%. In patients with stage III generalized periodontitis who underwent staged periodontal treatment and dental implantation, the safety of implants was 80,2%, and in patients who underwent one-stage dental implantation and periodontal treatment - 51,7%.