Photo-uncaging a Ru(II) intercalator via photodecomposition of a bridged Mn(I) photoCORM

Chem Commun (Camb). 2021 Aug 3;57(62):7713-7716. doi: 10.1039/d1cc02371c.

Abstract

A Ru(ii) intercalating complex capped with a Mn(i) photoCORM allows for a new mode of DNA intercalator delivery. The steric bulk of the Mn(i) photoCORM inhibits intercalation in the dark, and visible light irradiation (470 nm) dissociates the photoCORM, allowing for DNA intercalation of the Ru(ii) complex.

MeSH terms

  • Coordination Complexes* / chemistry
  • Coordination Complexes* / radiation effects
  • DNA* / chemistry
  • Intercalating Agents* / chemistry
  • Light*
  • Manganese* / chemistry
  • Molecular Structure
  • Photochemical Processes
  • Ruthenium* / chemistry

Substances

  • Ruthenium
  • Manganese
  • Intercalating Agents
  • DNA
  • Coordination Complexes