Abstract
This retrospective and single-center study in Reunion Island (Indian Ocean) assessed frequency, mortality, causative pathogens of severe necrotizing skin, and necrotizing skin and soft tissue infections (NSSTIs) admitted in intensive care unit (ICU). Sixty-seven consecutive patients were included from January 2012 to December 2018. Necrotizing skin and soft tissue infection represented 1.06% of total ICU admissions. We estimate the incidence of NSSTI requiring ICU at 1.21/100,000 person/years in Reunion Island. Twenty (30%) patients were receiving nonsteroidal anti-inflammatory drugs (NSAIDs) prior to admission in ICU and 40 (60%) were diagnosed patients with diabetes. Sites of infection were the lower limb in 52 (78%) patients, upper limb in 4 (6%), and perineum in 10 (15%). The surgical treatment was debridement for 40 patients, whereas 11 patients required an amputation. The most commonly isolated microorganisms were Streptococci (42%) and Gram-negative bacteria (22%).The mortality rate was 25.4%. NSAIDs did not influence mortality when interrupted upon admission to ICU.
MeSH terms
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Aged
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Amputation, Surgical
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arteritis / epidemiology
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Comorbidity
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Debridement
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / epidemiology
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Fasciitis, Necrotizing / epidemiology*
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Fasciitis, Necrotizing / mortality
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Fasciitis, Necrotizing / therapy
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Female
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Fluid Therapy
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Gram-Negative Bacterial Infections / epidemiology
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Gram-Negative Bacterial Infections / mortality
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Gram-Negative Bacterial Infections / therapy
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Hospital Mortality
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Humans
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Hypertension / epidemiology
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Hypoglycemic Agents / therapeutic use
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Intensive Care Units
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Male
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Middle Aged
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Necrosis
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Renal Insufficiency, Chronic / epidemiology
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Renal Replacement Therapy
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Respiration, Artificial
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Retrospective Studies
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Reunion / epidemiology
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Risk Factors
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Shock, Septic / epidemiology*
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Shock, Septic / mortality
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Shock, Septic / therapy
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Skin Diseases, Infectious
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Soft Tissue Infections / epidemiology*
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Soft Tissue Infections / mortality
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Soft Tissue Infections / therapy
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Staphylococcal Infections / epidemiology
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Staphylococcal Infections / mortality
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Staphylococcal Infections / therapy
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Staphylococcus aureus
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Streptococcal Infections / epidemiology*
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Streptococcal Infections / mortality
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Streptococcal Infections / therapy
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Streptococcus
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Streptococcus pyogenes
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Vasoconstrictor Agents / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Hypoglycemic Agents
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Vasoconstrictor Agents