Neisseria meningitidis Serogroup Z Meningitis in a Child With Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

Bryan van den Broek; Jordy P M Coolen; Marien I de Jonge; Ronald de Groot; Stefanie S V Henriet; Jeroen D Langereis; Michiel van der Flier

doi:10.1097/INF.0000000000003259

Neisseria meningitidis Serogroup Z Meningitis in a Child With Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

Pediatr Infect Dis J. 2021 Nov 1;40(11):1019-1022. doi: 10.1097/INF.0000000000003259.

Authors

Bryan van den Broek^{1

2

3}, Jordy P M Coolen^{3

4}, Marien I de Jonge^{2

3}, Ronald de Groot^{2

3}, Stefanie S V Henriet^{1

3

5}, Jeroen D Langereis^{2

3}, Michiel van der Flier^{1

2

3

5

6}

Affiliations

¹ From the Pediatric Infectious Diseases and Immunology, Amalia Children's Hospital, Nijmegen, the Netherlands.
² Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, the Netherlands.
³ Radboud Center for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
⁴ Department of Medical Microbiology, Radboudumc, Nijmegen, the Netherlands.
⁵ Expertise Center for Immunodeficiency and Autoinflammation (REIA), Radboudumc, Nijmegen, the Netherlands.
⁶ Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands.

PMID: 34285166
DOI: 10.1097/INF.0000000000003259

Abstract

Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.

Publication types

Case Reports

MeSH terms

Antibodies, Bacterial / immunology
Child
Complement C8 / deficiency*
Cross Protection / immunology*
Cross Reactions / immunology
Female
Hereditary Complement Deficiency Diseases
Humans
Meningitis / diagnosis
Meningitis / immunology
Meningitis / microbiology*
Meningococcal Infections / prevention & control
Meningococcal Vaccines / administration & dosage
Meningococcal Vaccines / immunology*
Neisseria meningitidis / classification
Neisseria meningitidis / immunology*
Opsonization
Serogroup*

Substances

Antibodies, Bacterial
Complement C8
Meningococcal Vaccines