Hotel quarantine for international travelers has been used to prevent coronavirus disease spread into Australia. A quarantine hotel-associated community outbreak was detected in South Australia. Real-time genomic sequencing enabled rapid confirmation tracking the outbreak to a recently returned traveler and linked 2 cases of infection in travelers at the same facility.
Keywords: Australia; COVID-19; SARS-CoV-2; coronavirus disease; genome sequencing; hotel quarantine; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccines; viruses; zoonoses.