Unstable pelvic ring disruption is most commonly treated with closed reduction and percutaneous screw fixation. Traditional methods involve screw placement under fluoroscopic imaging, but with recent technologic advances, intraoperative 3D navigation can now be used to help with the insertion of sacroiliac screws. Various cadaver studies have shown that placement of sacroiliac screws under 3D navigation is more accurate than placement under traditional fluoroscopic guidance. This retrospective review of 134 patients evaluated the clinical use of 3D navigation vs traditional fluoroscopy for sacroiliac screw insertion at an urban level I trauma center. Analysis of surgical data showed a significantly longer imaging time with the conventional method compared with the more experimental 3D navigation (204.06 seconds vs 66.90 seconds, P<.01). Further, a significantly larger radiation dose to both the patient and the staff was seen with traditional fluoroscopy (80.1 mGy for each) compared with that of 3D navigation (39.0 mGy and 25.1 mGy, respectively). No statistically significant difference was seen for outcome or follow-up variables between the 2 extrapolated groups. These variables included length of hospital stay, infection, nerve injury, and hardware breakage. The authors advocate that 3D navigated sacroiliac screws are safe and effective for pelvic ring stabilization; this method may be especially applicable in certain difficult imaging situations, such as morbid obesity, bowel gas interference, and overlapping pelvic structures that make the sacral corridor difficult to discern with traditional 2D fluoroscopy. Safe placement of transiliac-transsacral screws (P<.01) occurred with 3D navigation, and there was a statistically significant increase in adequate screw placement in multiple sacral segments compared with single-level stabilization (P<.01). [Orthopedics. 2021;44(4):229-234.].