Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile

Neuropathol Appl Neurobiol. 2022 Feb;48(2):e12754. doi: 10.1111/nan.12754. Epub 2021 Aug 9.

Abstract

We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.

Keywords: adrenocortical cells; choristoma; corticotroph tumour.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ACTH-Secreting Pituitary Adenoma / genetics
  • ACTH-Secreting Pituitary Adenoma / metabolism
  • ACTH-Secreting Pituitary Adenoma / pathology*
  • Adult
  • Corticotrophs / metabolism
  • Corticotrophs / pathology*
  • DNA Methylation*
  • Humans
  • Male
  • Pituitary Gland / metabolism
  • Pituitary Gland / pathology*
  • Pituitary Neoplasms / genetics
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology*