The use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in coronavirus disease 2019 (COVID-19) patients has been claimed as associated with the risk of COVID-19 infection and its subsequent morbidities and mortalities. These claims were resulting from the possibility of upregulating the expression of angiotensin-converting enzyme 2 (ACE2), facilitation of SARS-CoV-2 entry, and increasing the susceptibility of infection in such treated cardiovascular patients. ACE2 and renin-angiotensin-aldosterone system (RAAS) products have a critical function in controlling the severity of lung injury, fibrosis, and failure following the initiation of the disease. This review is to clarify the mechanisms beyond the possible deleterious effects of angiotensin II (Ang II), and the potential protective role of angiotensin 1-7 (Ang 1-7) against pulmonary fibrosis, with a subsequent discussion of the latest updates on ACEIs/ARBs use and COVID-19 susceptibility in the light of these mechanisms and biochemical explanation.
Keywords: ACE1, angiotensin-converting enzyme 1; ACE2; ACE2, angiotensin-converting enzyme 2; ACEIs; ACEIs, angiotensin-converting enzyme inhibitors; AEC-II, alveolar epithelial type II cells; ARBs; ARBs, angiotensin receptor blockers; AT1R, angiotensin type 1 receptor; AT2R, angiotensin type 2 receptor; Ang 1-7, angiotensin 1-7; Ang 1-9, angiotensin 1-9; AngI, angiotensin I; AngII, angiotensin II; Angiotensin 1–7; Angiotensin II; COVID-19; COVID-19, coronavirus disease 2019; CVD, cardiovascular disease; ERK, extracellular signal-regulated kinase; ICU, intensive care unit; MAPK, mitogen-activated protein kinase; NLRP3, (NOD, LRR, and pyrin domain-containing protein 3); RAAS, renin-angiotensin-aldosterone system; TGF-β, transforming growth factor-beta; miR-21, microRNA-21.
© 2021 The Author(s).