Quinofuracins F - I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444

Daisuke Tatsuda; Masahide Amemiya; Ryuichi Sawa; Isao Momose; Manabu Kawada

doi:10.1038/s41429-021-00452-z

Quinofuracins F - I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444

J Antibiot (Tokyo). 2021 Oct;74(10):758-762. doi: 10.1038/s41429-021-00452-z. Epub 2021 Jul 29.

Authors

Daisuke Tatsuda¹, Masahide Amemiya¹, Ryuichi Sawa¹, Isao Momose², Manabu Kawada¹

Affiliations

¹ Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Japan.
² Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan. [email protected].

PMID: 34326482
DOI: 10.1038/s41429-021-00452-z

Abstract

Four new quinofuracins F - I were isolated from the culture broth of Staphylotrichum boninense PF1444. The structures of quinofuracins F - I were elucidated by extensive spectroscopic analysis. These quinofuracins induced tumor suppressor protein p53-dependent cell death in human glioblastoma LNZTA3 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Ascomycota / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
Gene Expression Regulation, Neoplastic / drug effects
Glioblastoma
Humans
Molecular Structure
Nitrofurazone / analogs & derivatives*
Nitrofurazone / chemistry*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism

Substances

Antineoplastic Agents
Tumor Suppressor Protein p53
Nitrofurazone

Supplementary concepts

Staphylotrichum boninense