Mycobacterial lymphadenitis without granuloma formation in a patient with anti-interferon-gamma antibodies

Int J Hematol. 2021 Nov;114(5):630-635. doi: 10.1007/s12185-021-03199-3. Epub 2021 Jul 30.

Abstract

A previously healthy 49-year-old Japanese woman presented with cervical lymph node swelling and tenderness. Lymph node biopsy revealed reactive lymphadenitis without granulomas. No malignant cells were found, and no acid-fast positive bacilli were identified by Ziehl-Neelsen staining. She was treated unsuccessfully with various antibiotics, and it was very challenging to reach a diagnosis. 18F-Fluorodeoxyglucose (18F-FDG) uptake in bones was evaluated using positron emission tomography-computed tomography (PET-CT), and disseminated mycobacterial infection was suspected. The interferon-gamma (IFN-γ) release assays QuantiFERON (QFT) and T-SPOT were used to diagnose tuberculosis infection. On testing, a difference in mitogen response was found between these assays. The response was low for QFT but adequate for T-SPOT, suggesting the presence of anti-IFN-γ antibodies. This difference depended on whether the patient's plasma (including anti-IFN-γ antibodies) was used within the assay system. Mycobacterium abscessus was isolated from lymph node cultures, and plasma anti-IFN-γ antibodies were confirmed. The patient was diagnosed with disseminated M. abscessus infection with underlying adult-onset immunodeficiency caused by anti-IFN-γ antibodies. Granulomas are a pathological hallmark of mycobacterial infection, but may not fully form in immunodeficient patients. Clinicians should be aware of the possibility of mycobacterial infection without granuloma formation due to anti-IFN-γ antibodies.

Keywords: Anti-interferon-gamma antibodies; IFN-γ release assay; Mitogen response; Mycobacterial infection; QuantiFERON; T-SPOT.

MeSH terms

  • Antibodies / blood
  • Antibodies / immunology*
  • Disease Management
  • Disease Susceptibility
  • Female
  • Granuloma / diagnosis*
  • Granuloma / etiology*
  • Humans
  • Immunohistochemistry
  • Interferon-gamma / immunology*
  • Lymphadenitis / diagnosis*
  • Lymphadenitis / etiology*
  • Middle Aged
  • Mycobacterium Infections, Nontuberculous / diagnosis*
  • Mycobacterium Infections, Nontuberculous / microbiology*
  • Positron-Emission Tomography
  • Symptom Assessment

Substances

  • Antibodies
  • Interferon-gamma