Urinary tract infections in cystic fibrosis patients

J Cyst Fibros. 2022 Jan;21(1):e1-e4. doi: 10.1016/j.jcf.2021.07.005. Epub 2021 Jul 27.

Abstract

Improved understanding of non-respiratory infections in cystic fibrosis (CF) patients will be vital to sustaining the increased life span of these patients. To date, there has not been a published report of urinary tract infections (UTIs) in CF patients. We performed a retrospective chart review at a major academic medical center during 2010-2020 to determine the features of UTIs in 826 CF patients. We identified 108 UTI episodes during this period. Diabetes, distal intestinal obstruction syndrome (DIOS), and nephrolithiasis were correlated with increased risk of UTIs. UTIs in CF patients were less likely to be caused by Gram-negative rods compared to non-CF patients and more likely to be caused by Enterococcus faecalis. The unique features of UTIs in CF patients highlight the importance of investigating non-respiratory infections to ensure appropriate treatment.

Keywords: Antibiotic resistance; Cystic fibrosis; Cystitis; Urinary tract infection.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Child
  • Cystic Fibrosis / complications*
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Risk Factors
  • Urinary Tract Infections / complications*
  • Urinary Tract Infections / drug therapy
  • Urinary Tract Infections / microbiology*
  • Young Adult

Substances

  • Anti-Bacterial Agents