The SRSF4-GAS5-Glucocorticoid Receptor Axis Regulates Ventricular Hypertrophy

Circ Res. 2021 Sep 3;129(6):669-683. doi: 10.1161/CIRCRESAHA.120.318577. Epub 2021 Aug 2.

Abstract

[Figure: see text].

Keywords: RNA-binding proteins; cardiovascular disease; glucocorticoid receptor; left ventricular hypertrophy; long noncoding RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Hypertrophy, Left Ventricular / genetics
  • Hypertrophy, Left Ventricular / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocytes, Cardiac / metabolism
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*
  • Receptors, Glucocorticoid / genetics
  • Receptors, Glucocorticoid / metabolism*
  • Serine-Arginine Splicing Factors / genetics
  • Serine-Arginine Splicing Factors / metabolism*
  • Transcriptome

Substances

  • RNA, Long Noncoding
  • RNA-Binding Proteins
  • Receptors, Glucocorticoid
  • Srsf4 protein, mouse
  • Serine-Arginine Splicing Factors