Decreased fasting serum glucogenic amino acids with a higher compared to normal protein diet during energy restriction in women: a randomized controlled trial

Amino Acids. 2021 Sep;53(9):1467-1472. doi: 10.1007/s00726-021-03053-0. Epub 2021 Aug 2.

Abstract

Dietary protein alters circulating amino acid (AAs) levels and higher protein intake (HP) is one means of losing weight. We examined 34 overweight and obese women (57 ± 4 years) during 6 months of energy restriction (7.3 ± 3.8% weight loss) divided into groups consuming either normal protein (NP; 18.6 energy% protein) or HP (24.3 energy% protein). There was a reduction in fasting serum glucogenic AAs (p = 0.015) that also associated with greater weight loss (p < 0.05) in the HP group, but not in the NP group. These findings have implications for nutrient prioritization during energy restriction.

Keywords: Diet; Glucogenic amino acids; Lysine; Protein; Weight loss.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Amino Acids / blood*
  • Body Composition
  • Diet*
  • Dietary Proteins / administration & dosage*
  • Energy Intake*
  • Fasting
  • Female
  • Humans
  • Middle Aged
  • Obesity / blood
  • Obesity / diet therapy*
  • Overweight / blood
  • Overweight / diet therapy*
  • Weight Loss*

Substances

  • Amino Acids
  • Dietary Proteins