Prediction of EGFR Mutation Status Based on ¹⁸F-FDG PET/CT Imaging Using Deep Learning-Based Model in Lung Adenocarcinoma

Objective: The purpose of this study was to develop a deep learning-based system to automatically predict epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma in ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT).

Methods: Three hundred and one lung adenocarcinoma patients with EGFR mutation status were enrolled in this study. Two deep learning models (SE_CT and SE_PET) were developed with Squeeze-and-Excitation Residual Network (SE-ResNet) module for the prediction of EGFR mutation with CT and PET images, respectively. The deep learning models were trained with a training data set of 198 patients and tested with a testing data set of 103 patients. Stacked generalization was used to integrate the results of SE_CT and SE_PET.

Results: The AUCs of the SE_CT and SE_PET were 0.72 (95% CI, 0.62-0.80) and 0.74 (95% CI, 0.65-0.82) in the testing data set, respectively. After integrating SE_CT and SE_PET with stacked generalization, the AUC was further improved to 0.84 (95% CI, 0.75-0.90), significantly higher than SE_CT (p<0.05).

Conclusion: The stacking model based on ¹⁸F-FDG PET/CT images is capable to predict EGFR mutation status of patients with lung adenocarcinoma automatically and non-invasively. The proposed model in this study showed the potential to help clinicians identify suitable advanced patients with lung adenocarcinoma for EGFR-targeted therapy.