Sensing wounds by spilling cellular guts: Damage-associated protease release can initiate tissue repair

Maria-Del-Carmen Diaz-de-la-Loza; Yutaka Matsubayashi; Brian Marc Stramer

doi:10.1016/j.devcel.2021.07.013

Sensing wounds by spilling cellular guts: Damage-associated protease release can initiate tissue repair

Dev Cell. 2021 Aug 9;56(15):2137-2139. doi: 10.1016/j.devcel.2021.07.013.

Authors

Maria-Del-Carmen Diaz-de-la-Loza¹, Yutaka Matsubayashi¹, Brian Marc Stramer²

Affiliations

¹ Randall Centre for Cell and Molecular Biophysics, King's College London, London SE1 1UL.
² Randall Centre for Cell and Molecular Biophysics, King's College London, London SE1 1UL. Electronic address: [email protected].

PMID: 34375578
DOI: 10.1016/j.devcel.2021.07.013

Abstract

Epithelia have an innate yet mysterious capacity to rapidly sense and respond to tissue damage. In this issue of Developmental Cell, O'Connor et al. exploit the genetics of Drosophila to reveal that protease release as a result of tissue injury activates insect cytokines to initiate immediate epithelial repair responses.

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MeSH terms

Animals
Drosophila*
Epithelium
Peptide Hydrolases*

Substances

Peptide Hydrolases