Cell biology: How cancer cells coerce normal cells into tumorigenesis

Sushila Ganguli; Helen K Matthews

doi:10.1016/j.cub.2021.06.041

Cell biology: How cancer cells coerce normal cells into tumorigenesis

Curr Biol. 2021 Aug 9;31(15):R957-R959. doi: 10.1016/j.cub.2021.06.041.

Authors

Sushila Ganguli¹, Helen K Matthews²

Affiliations

¹ MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
² MRC Laboratory for Molecular Cell Biology, University College London, London, UK. Electronic address: [email protected].

PMID: 34375600
DOI: 10.1016/j.cub.2021.06.041

Abstract

The role of altered tissue mechanics in early cancer development is not well understood. A new study reveals how oncogene activation generates force within a tissue to impact cell division in surrounding normal cells, which then contribute to tumour formation.

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MeSH terms

Carcinogenesis*
Cell Division
Cell Transformation, Neoplastic
Humans
Neoplasms*