Extremely low 18F-fluorodeoxyglucose uptake in the brain of a patient with metastatic neuroblastoma and its recovery after chemotherapy: A case report

Yutaka Hoshino; Minako Sugiyama; Kenji Hirata; Shohei Honda; Hitoshi Saito; Atsushi Manabe; Kohsuke Kudo

doi:10.1177/20584601211026810

Extremely low ¹⁸F-fluorodeoxyglucose uptake in the brain of a patient with metastatic neuroblastoma and its recovery after chemotherapy: A case report

Acta Radiol Open. 2021 Jul 30;10(7):20584601211026810. doi: 10.1177/20584601211026810. eCollection 2021 Jul.

Authors

Yutaka Hoshino^{1

2}, Minako Sugiyama³, Kenji Hirata^{2

4}, Shohei Honda⁵, Hitoshi Saito⁶, Atsushi Manabe³, Kohsuke Kudo^{1

2

7}

Affiliations

¹ Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
² Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
³ Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
⁴ Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, Japan.
⁵ Department of Gastroenterological Surgery I, Hokkaido University Hospital, Sapporo, Japan.
⁶ Department of Anesthesiology and Critical Care Medicine, Hokkaido University Hospital, Sapporo, Japan.
⁷ Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Abstract

Commonly, physiological ¹⁸F-fluorodeoxyglucose (FDG) uptake in the brain can be observed in ¹⁸F-FDG positron emission tomography. Abnormal uptake of ¹⁸F-FDG in the brain suggests disorders of central nervous system. Here, we present a case of extremely low ¹⁸F-FDG uptake in the brain of a 4-year-old girl with whole-body metastatic neuroblastoma. Almost missing of physiological ¹⁸F-FDG uptake in the brain was ascribed at least partly to the metastatic neuroblastoma. The brain could regain physiological ¹⁸F-FDG uptake after chemotherapy.

Keywords: Brain; F-fluorodeoxyglucose; I-metaiodobenzylguanidine; neuroblastoma; positron emission tomography.

Publication types

Case Reports