Long chain non-encoding RNA (lncRNA) can affect gene expression through transcription, post transcriptional regulation and epigenetic modification, and it is involved in regulating ovarian physiological function. LncRNA, as a competitive endogenous RNA, can affect the expression of target gene mRNA by competitively binding microRNA (miRNA), which are called lncRNA/miRNA/mRNA regulatory network. It plays an important role in the regulation of ovarian physiological function and the occurrence and development of ovarian reproductive disorders, expecting to become a new target and diagnostic index for the treatment of reproductive disorders.
长链非编码RNA(long non-coding RNA，lncRNA)可通过转录、转录后调控及表观遗传修饰等影响基因的表达，参与调控卵巢生理功能。LncRNA还可作为竞争性内源RNA(competing endogenous RNA，ceRNA)，通过竞争性结合微RNA(micro RNA，miRNA)而影响靶基因mRNA的表达，该调控方式称为lncRNA/miRNA/mRNA调控网络。LncRNA/miRNA/mRNA网络在调控卵巢生理功能和卵巢生殖功能障碍性疾病的发生、发展中起重要作用，有望成为治疗生殖障碍性疾病的新靶点和诊断指标。.
Keywords: competing endogenous RNA; long non-coding RNA; ovarian function.