Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1-T587M

Asami Kashiwa; Yukio Hosaka; Kazuyoshi Takahashi; Seiko Ohno; Yuko Wada; Takeru Makiyama; Hirotaka Oda; Minoru Horie

doi:10.1002/joa3.12576

Pueraria mirifica, an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1-T587M

J Arrhythm. 2021 Jun 14;37(4):1114-1116. doi: 10.1002/joa3.12576. eCollection 2021 Aug.

Authors

Asami Kashiwa^{1

2}, Yukio Hosaka², Kazuyoshi Takahashi², Seiko Ohno³, Yuko Wada^{4

5}, Takeru Makiyama¹, Hirotaka Oda², Minoru Horie⁵

Affiliations

¹ Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan.
² Department of Cardiovascular Medicine Niigata City General Hospital Niigata Japan.
³ Department of Bioscience and Genetics National Cerebral and Cardiovascular Center Osaka Japan.
⁴ Vanderbilt Center for Arrhythmia Research and Therapeutics Division of Clinical Pharmacology Department of Medicine Vanderbilt University Medical Center Nashville TN USA.
⁵ Department of Cardiovascular Medicine Shiga University of Medical Science Shiga Japan.

Abstract

After taking an estrogen-containing supplement derived from a tropical plant Pueraria mirifica, a 24-year-old woman presented marked QT prolongation and repetitive torsade de pointes. The patient was found to carry a heterozygous KCNQ1-T587M mutation. This is the first report on Pueraria mirifica-related acquired long QT syndrome.

Keywords: acquired long QT syndrome; congenital long QT syndrome; drug‐induced long QT syndrome; estrogens; genetics.