Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome

Marcus Ståhlberg; Ulrika Reistam; Artur Fedorowski; Humberto Villacorta; Yu Horiuchi; Jeroen Bax; Bertram Pitt; Simon Matskeplishvili; Thomas F Lüscher; Immo Weichert; Khalid Bin Thani; Alan Maisel

doi:10.1016/j.amjmed.2021.07.004

Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome

Am J Med. 2021 Dec;134(12):1451-1456. doi: 10.1016/j.amjmed.2021.07.004. Epub 2021 Aug 11.

Authors

Affiliations

¹ Cardiology, Heart, Vascular and Neuro Theme, Karolinska University Hospital and Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: [email protected].
² Cardiology, Heart, Vascular and Neuro Theme, Karolinska University Hospital and Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden; Department of Cardiology, Skåne University Hospital, Malmö, Sweden.
⁴ Division of Cardiology, Fluminense Federal University, Niterói, Rio de Janeiro State, Brazil.
⁵ Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
⁶ Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
⁷ University of Michigan, Ann Arbor.
⁸ Lomonosov Moscow State University Medical Center, Moscow, Russia.
⁹ Heart Division, Royal Brompton & Harefield Hospitals and National Heart and Lung Institute, Imperial College, London, UK; Center for Molecular Cardiology, University of Zurich, Switzerland.
¹⁰ Acute Medicine Department, Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK.
¹¹ Department of Cardiology, Salmaniya Medical Complex, Manama, Bahrain.
¹² Division of Cardiovascular Medicine, University of California San Diego, La Jolla.

Abstract

In this paper we highlight the presence of tachycardia in post-acute COVID-19 syndrome by introducing a new label for this phenomenon-post-COVID-19 tachycardia syndrome-and argue that this constitutes a phenotype or sub-syndrome in post-acute COVID-19 syndrome. We also discuss epidemiology, putative mechanisms, treatment options, and future research directions in this novel clinical syndrome.

Keywords: COVID-19; Inappropriate sinus tachycardia; Postural orthostatic tachycardia syndrome; Tachycardia.

Publication types

Review

MeSH terms

COVID-19 / complications*
COVID-19 / physiopathology
COVID-19 / therapy
Humans
Phenotype
Post-Acute COVID-19 Syndrome
SARS-CoV-2
Syndrome
Tachycardia, Sinus* / etiology
Tachycardia, Sinus* / genetics
Tachycardia, Sinus* / physiopathology
Tachycardia, Sinus* / surgery