[Combination radiotherapy-immunotherapy in genitourinary cancer]

L Ollivier; V Guimas; E Rio; L Vaugier; I Masson; V Libois; M Labbé; D Fradin; V Potiron; S Supiot

doi:10.1016/j.canrad.2021.06.033

[Combination radiotherapy-immunotherapy in genitourinary cancer]

Cancer Radiother. 2021 Oct;25(6-7):565-569. doi: 10.1016/j.canrad.2021.06.033. Epub 2021 Aug 12.

[Article in French]

Authors

L Ollivier¹, V Guimas², E Rio², L Vaugier², I Masson², V Libois², M Labbé³, D Fradin³, V Potiron², S Supiot⁴

Affiliations

¹ Institut de cancérologie de l'Ouest, département de radiothérapie, boulevard Jacques-Monod, 44800 Nantes Saint Herblain, France; Inserm UMR1232, CNRS ERL 6001, centre de recherche en cancérologie Nantes-Atlantique CRCINA-institut de recherche en santé de l'université de Nantes, 8, quai Moncousu, BP 70721, 44007 Nantes cedex1, France.
² Institut de cancérologie de l'Ouest, département de radiothérapie, boulevard Jacques-Monod, 44800 Nantes Saint Herblain, France.
³ Inserm UMR1232, CNRS ERL 6001, centre de recherche en cancérologie Nantes-Atlantique CRCINA-institut de recherche en santé de l'université de Nantes, 8, quai Moncousu, BP 70721, 44007 Nantes cedex1, France.
⁴ Institut de cancérologie de l'Ouest, département de radiothérapie, boulevard Jacques-Monod, 44800 Nantes Saint Herblain, France. Electronic address: [email protected].

PMID: 34391648
DOI: 10.1016/j.canrad.2021.06.033

Abstract

Immunotherapy occupies a growing place in urologic oncology, mainly for kidney and bladder cancers. On the basis of encouraging preclinical work, the combination of immunotherapy with radiotherapy aims to increase the tumor response, including in metastatic tumors, which raises many hopes, which this article reviews.

Keywords: Bladder cancer; CTLA4; Cancer de la vessie; Cancer du rein; Immune check point inhibition; Inhibition des points de contrôle immunitaire; Kidney cancer; Néoplasme de la prostate; PD1; PDL1; PDL1, CTLA4; Prostate neoplasm; Radiation oncology; Radio-oncologie; Radiothérapie stéréotaxique; Stereotactic body radiation therapy.

Publication types

Review

MeSH terms

Combined Modality Therapy / methods
Humans
Immune Checkpoint Inhibitors / therapeutic use*
Immunomodulation
Kidney Neoplasms / immunology
Kidney Neoplasms / therapy*
Male
Prostatic Neoplasms / immunology
Prostatic Neoplasms / therapy*
Radiotherapy / methods*
Urinary Bladder Neoplasms / immunology
Urinary Bladder Neoplasms / therapy*

Substances

Immune Checkpoint Inhibitors