Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging

Circ Res. 2021 Sep 17;129(7):e121-e140. doi: 10.1161/CIRCRESAHA.121.318897. Epub 2021 Aug 17.

Abstract

[Figure: see text].

Keywords: aging; exosomes; inflammation; ischemic stroke; microglia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / blood*
  • Aging / immunology
  • Animals
  • Complement System Proteins / metabolism
  • Exosomes / immunology*
  • Male
  • Membrane Cofactor Protein / genetics
  • Membrane Cofactor Protein / metabolism
  • Microglia / immunology
  • Phagocytosis
  • Rats
  • Rats, Inbred F344
  • Stroke / blood*
  • Stroke / immunology
  • Stroke / pathology

Substances

  • Membrane Cofactor Protein
  • Complement System Proteins