Cep55: abscission boss or assistant?

Jessica N Little; Noelle D Dwyer

doi:10.1016/j.tcb.2021.07.006

Cep55: abscission boss or assistant?

Trends Cell Biol. 2021 Oct;31(10):789-791. doi: 10.1016/j.tcb.2021.07.006. Epub 2021 Aug 13.

Authors

Jessica N Little¹, Noelle D Dwyer²

Affiliations

¹ Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.
² Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: [email protected].

Abstract

Abscission is the second stage of cytokinesis. Cep55, a coiled-coil protein, is thought to recruit endosomal sorting complexes required for transport (ESCRTs) to the midbody to complete abscission. However, recent studies of Cep55-knockout mice reveal that most cells can complete abscission without Cep55. More work is needed to understand abscission mechanisms in different cell types.

Keywords: Cep55; ESCRT; abscission; cytokinesis; midbody; mouse.

MeSH terms

Animals
Cell Cycle Proteins* / genetics
Cytokinesis*
Endosomal Sorting Complexes Required for Transport / genetics
Mice

Substances

Cell Cycle Proteins
Endosomal Sorting Complexes Required for Transport

Abstract

MeSH terms

Substances

Grants and funding