RETRACTED: Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer

Sanaz Taromi; Elke Firat; Alexander Simonis; Lukas M Braun; Petya Apostolova; Mirjam Elze; Bernward Passlick; Alicia Schumacher; Simon Lagies; Anna Frey; Annette Schmitt-Graeff; Meike Burger; Katrin Schmittlutz; Marie Follo; Dominik von Elverfeldt; Xuekai Zhu; Bernd Kammerer; Sven Diederichs; Justus Duyster; Markus G Manz; Gabriele Niedermann; Robert Zeiser

doi:10.1016/j.canlet.2021.08.012

RETRACTED: Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer

Cancer Lett. 2021 Nov 1:520:385-399. doi: 10.1016/j.canlet.2021.08.012. Epub 2021 Aug 15.

Authors

Sanaz Taromi¹, Elke Firat², Alexander Simonis³, Lukas M Braun⁴, Petya Apostolova⁴, Mirjam Elze⁵, Bernward Passlick⁵, Alicia Schumacher⁴, Simon Lagies⁶, Anna Frey⁷, Annette Schmitt-Graeff⁷, Meike Burger⁸, Katrin Schmittlutz⁴, Marie Follo⁴, Dominik von Elverfeldt⁹, Xuekai Zhu¹⁰, Bernd Kammerer¹¹, Sven Diederichs¹², Justus Duyster¹³, Markus G Manz³, Gabriele Niedermann¹⁴, Robert Zeiser¹⁵

Affiliations

¹ Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; University Furtwangen, Faculty of Medical and Life Sciences, Campus VS-Schwenningen, Germany. Electronic address: [email protected].
² Department of Radiation Oncology, Faculty of Medicine, University of Freiburg, Germany.
³ Department of Medical Oncology and Hematology and Oncology, Zurich University and University Hospital Medical Center Zurich, Zurich, Switzerland.
⁴ Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
⁵ Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
⁶ Center for Biological Systems Analysis (ZBSA), University of Freiburg, Freiburg, Germany; Institute of Biology II, Albert-Ludwigs-University Freiburg, Freiburg, Germany; Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
⁷ Department of Pathology, Freiburg University Medical Center, Albert-Ludwigs-University (ALU) Freiburg, Freiburg, Germany.
⁸ Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; University Furtwangen, Faculty of Medical and Life Sciences, Campus VS-Schwenningen, Germany.
⁹ Medical Physics, Freiburg University Medical Center, Faculty of Medicine, Albert-Ludwigs-University (ALU) Freiburg, Freiburg, Germany.
¹⁰ Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai, China.
¹¹ Center for Biological Systems Analysis (ZBSA), University of Freiburg, Freiburg, Germany; Institute of Biology II, Albert-Ludwigs-University Freiburg, Freiburg, Germany; Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany; BIOSS Center for Biological Signalling Studies, University of Freiburg, Germany.
¹² Department of Thoracic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹³ Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁴ Department of Radiation Oncology, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; BIOSS Center for Biological Signalling Studies, University of Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, Germany.

PMID: 34407431
DOI: 10.1016/j.canlet.2021.08.012

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Following the publication of the above article, the Editor was notified that an error occurred in which all images were published with incorrect versions. The Editor has taken the decision that the manuscript is no longer acceptable in its current form, nor with a corrigendum, as the extensive changes to the figures and publication would lead to ambiguity for our readers. We have therefore made the decision to retract this manuscript from Cancer Letters with the possibility of resubmission and republication of the manuscript in its corrected form after peer review.

Keywords: CAR T cells; CD133; CD73; PD-1; SCLC.

Publication types

Research Support, Non-U.S. Gov't
Retracted Publication

MeSH terms

5'-Nucleotidase / antagonists & inhibitors
5'-Nucleotidase / genetics*
AC133 Antigen / genetics*
AC133 Antigen / immunology
Animals
Antibodies, Anti-Idiotypic / pharmacology
B7-H1 Antigen / antagonists & inhibitors
B7-H1 Antigen / genetics*
Cell Line, Tumor
Female
Heterografts
Humans
Immunotherapy, Adoptive / trends
Male
Mice
Neoplasm Metastasis
Neoplastic Stem Cells / drug effects
Neoplastic Stem Cells / immunology
Neoplastic Stem Cells / pathology
Programmed Cell Death 1 Receptor / antagonists & inhibitors
Programmed Cell Death 1 Receptor / genetics
Receptors, Chimeric Antigen / genetics
Receptors, Chimeric Antigen / immunology
Receptors, Chimeric Antigen / therapeutic use
Small Cell Lung Carcinoma / genetics
Small Cell Lung Carcinoma / immunology
Small Cell Lung Carcinoma / pathology
Small Cell Lung Carcinoma / therapy*
T-Lymphocytes / immunology
Tumor Burden

Substances

AC133 Antigen
Antibodies, Anti-Idiotypic
B7-H1 Antigen
Programmed Cell Death 1 Receptor
Receptors, Chimeric Antigen
5'-Nucleotidase