Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation

A Leonardi; L Arata; M Farinelli; L Cocito; A Schenone; M Tabaton; G L Mancardi

doi:10.1016/0022-510x(87)90024-4

Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation

J Neurol Sci. 1987 Dec;82(1-3):281-90. doi: 10.1016/0022-510x(87)90024-4.

Authors

A Leonardi¹, L Arata, M Farinelli, L Cocito, A Schenone, M Tabaton, G L Mancardi

Affiliation

¹ Department of Clinical Neurology, University of Genoa, Italy.

PMID: 3440870
DOI: 10.1016/0022-510x(87)90024-4

Abstract

Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central nervous system vasculitis and leptomeningitis. As a whole, our CSF and neuropathological findings in DS are consistently different from those in multiple sclerosis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Albumins / cerebrospinal fluid
Central Nervous System / pathology
Demyelinating Diseases / cerebrospinal fluid*
Diagnosis, Differential
Female
Humans
Immunoglobulin G / cerebrospinal fluid
Isoelectric Focusing
Middle Aged
Multiple Sclerosis / cerebrospinal fluid
Neuromyelitis Optica / cerebrospinal fluid*
Neuromyelitis Optica / immunology
Neuromyelitis Optica / pathology

Substances

Albumins
Immunoglobulin G