Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat

Circ Res. 2021 Sep 17;129(7):720-734. doi: 10.1161/CIRCRESAHA.121.319517. Epub 2021 Aug 21.

Abstract

[Figure: see text].

Keywords: catalase; endothelium; fasting; glucose; insulin; microRNAs; muscles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Cells, Cultured
  • Diabetes Mellitus, Type 2 / metabolism*
  • Endothelium, Vascular / metabolism*
  • Glucose / metabolism*
  • Humans
  • Hydrogen Peroxide / metabolism
  • Insulin / metabolism
  • Insulin-Like Growth Factor I / metabolism
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Muscle, Skeletal / metabolism*
  • NADPH Oxidase 4 / genetics
  • NADPH Oxidase 4 / metabolism
  • Paracrine Communication*
  • Receptor, IGF Type 1 / genetics
  • Receptor, IGF Type 1 / metabolism

Substances

  • Igf1r protein, mouse
  • Insulin
  • MIRN25 microRNA, mouse
  • MicroRNAs
  • Insulin-Like Growth Factor I
  • Hydrogen Peroxide
  • NADPH Oxidase 4
  • Nox4 protein, mouse
  • Receptor, IGF Type 1
  • Glucose