RETRACTED: Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects

Neurotoxicology. 2021 Dec:87:1-10. doi: 10.1016/j.neuro.2021.08.010. Epub 2021 Aug 21.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editors-in-Chief. Figure 1C appears similar to Figure 5h of the article published by Oxidative Medicine and Cellular Longevity 2021 (2021) Article ID 6635552 https://doi.org/10.1155/2021/6635552, Figure 5a of the article published by Cells 10 (2021) 2719 https://doi.org/10.3390/cells10102719 and Figure 8a of the article published by Molecular Neurobiology 56 (2019) 6293–6309 https://doi.org/10.1007/s12035-019-1512-7. Although this article was published earlier than the Cells article, the Editors decided to retract this article given concerns about the reliability of the data. Also, sections of panels within Figures 1H and 2G appear similar to each other. The journal records indicated that the names of the authors Reem Alshaman and Muhammad Imran Khan were added to the revised version of the article without exceptional approval by the handling Editor, which is contrary to the journal policy on changes to authorship.

Keywords: Chemotherapy; Cisplatin; Melatonin; Neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Blotting, Western
  • Brain / drug effects*
  • Cisplatin / antagonists & inhibitors
  • Cisplatin / toxicity*
  • Fluorescent Antibody Technique
  • Lipid Peroxidation / drug effects
  • Male
  • Melatonin / pharmacology*
  • Mice
  • Morris Water Maze Test
  • Neurodegenerative Diseases / chemically induced*
  • Neurodegenerative Diseases / drug therapy
  • Neuroinflammatory Diseases / chemically induced
  • Neuroinflammatory Diseases / drug therapy
  • Neuroprotective Agents / pharmacology*
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / metabolism

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Neuroprotective Agents
  • Reactive Oxygen Species
  • Melatonin
  • Cisplatin