Abstract
The tetrapeptides CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe (n = 1-5) have been synthesized. These peptides containing an omega-amino acid residue in position 4 exhibit a very high chemotactic activity. Like the chemotactic peptide CHO-Met-Leu-Phe-OMe, these tetrapeptides in solution undoubtedly adopt an "active" conformation which allows a strong interaction with the receptor on the human polymorphonuclear leukocyte surface.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Movement / drug effects
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Chemical Phenomena
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Chemistry
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Chemotactic Factors / chemical synthesis*
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Chemotactic Factors / pharmacology
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Chemotaxis, Leukocyte / drug effects*
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Humans
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In Vitro Techniques
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Molecular Conformation
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Neutrophils / drug effects
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Oligopeptides / chemical synthesis*
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Oligopeptides / pharmacology
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Structure-Activity Relationship
Substances
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Chemotactic Factors
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Oligopeptides