Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review

Kuo-Tung Tang; Hsin-Hua Chen; Tzu-Ting Chen; Nicole R Bracci; Chi-Chien Lin

doi:10.3390/life11080801

Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review

Life (Basel). 2021 Aug 9;11(8):801. doi: 10.3390/life11080801.

Authors

Kuo-Tung Tang^{1

2

3}, Hsin-Hua Chen^{1

2

3

4

5}, Tzu-Ting Chen⁶, Nicole R Bracci⁷, Chi-Chien Lin^{3

4

8

9

10}

Affiliations

¹ Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
² Faculty of Medicine, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan.
³ Ph.D. Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
⁴ Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
⁵ Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung 40704, Taiwan.
⁶ Institute of Bioinformatics and Structural Biology and Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
⁷ Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
⁸ Institute of Biomedical Science, The iEGG and Animal Biotechnology Center, National Chung-Hsing University, Taichung 40227, Taiwan.
⁹ Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan.
¹⁰ Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease characterized by autoreactive B and T cells against β2-glycoprotein I (B2GPI), with vascular thrombosis or obstetrical complications. Dendritic cells (DCs) are crucial in the generation of autoimmunity. Here, we conducted a comprehensive systematic review on the relationship between DC and APS. We performed a literature search of PubMed as of 26 March 2021. A total of 33 articles were extracted. DCs are pivotal in inducing inflammatory responses and orchestrating adaptive immunity. DCs contribute to the local inflammation regarding vascular thrombosis or obstetrical complications. Both B2GPI and antiphospholipid antibodies (aPL) can promote antigen presentation by DCs and the generation or maintenance of autoimmunity. In addition, plasmacytoid DC activation is enhanced by aPL, thereby augmenting the inflammatory response. In line with these findings, DC modulation appears promising as a future treatment for APS. In conclusion, our review indicated the crucial role of DCs in the pathogenesis of APS. Deeper understanding of the complex relationship would help in developing new treatment strategies.

Keywords: antiphospholipid syndrome; autoimmunity; dendritic cell; immune tolerance; β2-glycoprotein I.

Publication types

Review

Abstract

Publication types

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