The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Guang-Fei Yang; Xin Zhang; Yi-Ge Su; Ren Zhao; Yan-Yang Wang

doi:10.1186/s12935-021-02160-y

The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review

Cancer Cell Int. 2021 Aug 28;21(1):455. doi: 10.1186/s12935-021-02160-y.

Authors

Guang-Fei Yang¹, Xin Zhang², Yi-Ge Su³, Ren Zhao^{4

5}, Yan-Yang Wang^{6

7}

Affiliations

¹ Dept. of Ultrasound, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
² School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
³ Graduate School, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
⁴ Dept. of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
⁵ Cancer Institute, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
⁶ Dept. of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, 750004, Ningxia, China. [email protected].
⁷ Cancer Institute, Ningxia Medical University, Yinchuan, 750004, Ningxia, China. [email protected].

Abstract

The balance between ubiquitination and deubiquitination is critical for the degradation, transport, localization, and activity of proteins. Deubiquitinating enzymes (DUBs) greatly contribute to the balance of ubiquitination and deubiquitination, and they have been widely studied due to their fundamental role in cancer. DUB3/ubiquitin-specific protease 17 (USP17) is a type of DUB that has attracted much attention in cancer research. In this review, we summarize the biological functions and regulatory mechanisms of USP17 in central nervous system, head and neck, thoracic, breast, gastrointestinal, genitourinary, and gynecologic cancers as well as bone and soft tissue sarcomas, and we provide new insights into how USP17 can be used in the management of cancer.

Keywords: Cancer; DUB3/USP17; Deubiquitinating enzymes; Signaling pathways; Ubiquitination.

Publication types

Review

Abstract

Publication types

Grants and funding