Abstract
In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Animals
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Apoptosis*
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Caspases / metabolism
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Embryonic Development
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Inflammation
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Mice
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Receptor-Interacting Protein Serine-Threonine Kinases / genetics
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Tumor Necrosis Factor-alpha* / metabolism
Substances
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Tumor Necrosis Factor-alpha
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Receptor-Interacting Protein Serine-Threonine Kinases
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Ripk1 protein, mouse
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Caspases