Storage of red blood cell concentrates: Clinical impact

E Längst; J-D Tissot; M Prudent

doi:10.1016/j.tracli.2021.08.344

Storage of red blood cell concentrates: Clinical impact

Transfus Clin Biol. 2021 Nov;28(4):397-402. doi: 10.1016/j.tracli.2021.08.344. Epub 2021 Aug 28.

Authors

E Längst¹, J-D Tissot², M Prudent³

Affiliations

¹ Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interrégionale CRS, Épalinges, Switzerland; Faculté de Biologie et de Médecine, université de Lausanne, Lausanne, Switzerland.
² Faculté de Biologie et de Médecine, université de Lausanne, Lausanne, Switzerland.
³ Laboratoire de Recherche sur les Produits Sanguins, Transfusion Interrégionale CRS, Épalinges, Switzerland; Faculté de Biologie et de Médecine, université de Lausanne, Lausanne, Switzerland; Center for Research and Innovation in Clinical Pharmaceutical Sciences, Institute of Pharmaceutical Sciences of Western Switzerland, University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: [email protected].

PMID: 34464712
DOI: 10.1016/j.tracli.2021.08.344

Abstract

The storage of red blood cells for transfusion purposes induces modifications of biochemical and biological properties. Moreover, these modifications are modulated by the donors' characteristics and the cell processing. These ex vivo alterations were suspected to decrease the transfusion efficiency and even to induce adverse events. This short article will review the red blood cells storage lesions and the clinical data related to them. In particular, the questions regarding the donors and recipients sex will be discussed.

Keywords: Clinical trial; Donor; Red blood cell; Sex; Storage lesions.

MeSH terms

Blood Preservation
Blood Transfusion*
Erythrocytes*
Humans