Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste

Yoichi Kasahara; Masataka Narukawa; Shinji Kanda; Makoto Tominaga; Keiko Abe; Takumi Misaka; Tomiko Asakura

doi:10.1093/bbb/zbab152

Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste

Biosci Biotechnol Biochem. 2021 Oct 21;85(11):2295-2299. doi: 10.1093/bbb/zbab152.

Authors

Yoichi Kasahara¹, Masataka Narukawa^{1

2}, Shinji Kanda³, Makoto Tominaga^{4

5}, Keiko Abe^{1

6}, Takumi Misaka¹, Tomiko Asakura¹

Affiliations

¹ Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan.
² Department of Food and Nutrition, Kyoto Women's University, Kitahiyoshicho Imakumano, Higashiyama, Kyoto, Japan.
³ Atmosphere and Ocean Research Institute, The University of Tokyo, Kashinoha Kashiwa City, Chiba, Japan.
⁴ Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Aza-Higashiyama, Myodaijicho, Okazaki, Aichi, Japan.
⁵ Thermal Biology Research Group, Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Aza-Higashiyama, Myodaijicho, Okazaki, Aichi, Japan.
⁶ Kanagawa Institute of Industrial Science and Technology (KISTEC), Life Science & Environment Research Center (LiSE) 4F C-4, Tonomachi Kawasaki-ku, Kawasaki, Kanagawa, Japan.

PMID: 34468713
DOI: 10.1093/bbb/zbab152

Abstract

Human susceptibility to NaCl varies depending on temperature and pH, the molecular mechanisms of which remain unclear. The voltage-dependent chloride channel, transmembrane channel-like 4 (TMC4), is activated at approximately 40 °C and is suppressed at pH 5.5. As these are similar in character to human sensory evaluations, human TMC4 may be involved in human salt taste reception.

Keywords: TMC4; pH; salty taste; temperature.

MeSH terms

Chloride Channels / metabolism
HEK293 Cells
Humans
Hydrogen-Ion Concentration
Sodium Chloride* / pharmacology
Taste* / physiology
Temperature*

Substances

Sodium Chloride
Chloride Channels

Abstract

MeSH terms

Substances

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