Optimization of retinopathy of prematurity screening in a tertiary neonatal unit in Northern Greece based on 16-year data

J Perinatol. 2022 Mar;42(3):365-370. doi: 10.1038/s41372-021-01196-2. Epub 2021 Sep 1.

Abstract

Objective: The optimal modification of retinopathy of prematurity (ROP) screening policy in our unit, by tightening the applicable screening criteria, without missing treatment-requiring ROP (TR-ROP).

Study design: Retrospective analysis of screened infants with gestational age (GA) < 32 weeks and/or birth weight (BW) < 1501 g as well as cases beyond these thresholds but with comorbidities (April 2004 to April 2020).

Result: Of 1560 included infants, 18.4% (n = 288) developed any stage of ROP and 3.1% (n = 49) were treated. TR-ROP occurred at a mean (SD) 362/7 (25/7) weeks PMA, and not before a minimum of 323/7 weeks PMA. No treated infant would have been missed if screening criteria were reduced to GA < 30 weeks and/or BW < 1251 g. This modification would have resulted in 826 (52.9%) fewer infants undergoing screening.

Conclusion: Modifying the current screening criteria to GA < 30 weeks and/or BW < 1251 g would have spared over half of the screened infants from unnecessary examinations, without missing TR-ROP.

MeSH terms

  • Birth Weight
  • Gestational Age
  • Greece / epidemiology
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Neonatal Screening / methods
  • Retinopathy of Prematurity* / diagnosis
  • Retinopathy of Prematurity* / epidemiology
  • Retinopathy of Prematurity* / therapy
  • Retrospective Studies
  • Risk Factors