Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Mol Cell. 2021 Sep 2;81(17):3445-3446. doi: 10.1016/j.molcel.2021.08.013.

Abstract

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

Publication types

  • Comment

MeSH terms

  • Chromatin
  • Humans
  • Interferon Regulatory Factors / genetics
  • Leukemia, Myeloid, Acute* / genetics
  • Tumor Suppressor Proteins* / genetics

Substances

  • Chromatin
  • Interferon Regulatory Factors
  • Tumor Suppressor Proteins