Clinical records from 4820 outpatients who required assistance after animal bites during 1986 at the "Antirabid Center" of Rome were collected and analysed. The study was carried out to investigate epidemiology of animal bites among our population and the proportion of people who received post-exposure antirabid prophylaxis. We noted a high proportion of people submitted to rabies immunization after animal bites (44% received at least one dose of HDCV vaccine), in spite of the fact that rabies is absent from Central Italy since many years in both wild and domestic animals (being present, on the contrary, in Northern Italy). These considerations suggest the opportunity of a substantial revision of the official Recommendations, and we feel that a differential policy should be adopted in rabies enzootic areas (Northern Italy) compared to those where risk is only potential.