Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates

Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2851-2853. doi: 10.1161/ATVBAHA.121.316590. Epub 2021 Sep 9.

Masayoshi Kukida¹, Lei Cai¹, Dien Ye^{1

2}, Hisashi Sawada^{1

3

4}, Yuriko Katsumata^{5

6}, Michael K Franklin¹, Peter I Hecker¹, Kenneth S Campbell⁴, A H Jan Danser², Adam E Mullick⁷, Alan Daugherty^{1

3

4}, Ryan E Temel^{1

4}, Hong S Lu^{1

3

4}

¹ Saha Cardiovascular Research Center (M.K., L.C., D.Y., H.S., M.K.F., P.I.H., A.D., R.E.T., H.S.L.), University of Kentucky, Lexington.
² Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands (D.Y., A.H.J.D.).
³ Saha Aortic Center (H.S., A.D., H.S.L.), University of Kentucky, Lexington.
⁴ Department of Physiology (H.S., K.S.C., A.D., R.E.T., H.S.L.), University of Kentucky, Lexington.
⁵ Department of Biostatistics (Y.K.), University of Kentucky, Lexington.
⁶ Sanders-Brown Center on Aging (Y.K.), University of Kentucky, Lexington.
⁷ Ionis Pharmaceuticals, Carlsbad, CA (A.E.M.).

Abstract

[Figure: see text].

Keywords: angiotensinogen; kidney; liver; oligonucleotides, antisense; renin-angiotensin system.