PDE1 Inhibition Modulates Cav1.2 Channel to Stimulate Cardiomyocyte Contraction

PDE1 Inhibition Modulates Ca_v1.2 Channel to Stimulate Cardiomyocyte Contraction

Circ Res. 2021 Oct 15;129(9):872-886. doi: 10.1161/CIRCRESAHA.121.319828. Epub 2021 Sep 15.

Grace K Muller¹, Joy Song¹, Vivek Jani¹, Yuejin Wu¹, Ting Liu¹, William P D Jeffreys¹, Brian O'Rourke^{1

2

3}, Mark E Anderson^{1

4

2}, David A Kass^{1

2

3}

¹ Division of Cardiology, Department of Medicine (G.K.M., J.S., V.J., Y.W., T.L., W.P.D.J., B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
² Graduate Program in Cellular and Molecular Medicine (B.O., M.E.A., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
³ Departments of Pharmacology and Molecular Sciences and Biomedical Engineering (B.O., D.A.K.), The Johns Hopkins University School of Medicine, Baltimore, MD.
⁴ Department of Physiology (M.E.A.), The Johns Hopkins University School of Medicine, Baltimore, MD.

[Figure: see text].

Keywords: excitation contraction coupling; myocardial contraction; nucleotide; pharmacology; phosphorylation.