Peripapillary Microvascularization Analysis Using Swept-Source Optical Coherence Tomography Angiography in Optic Chiasmal Compression

Inès Ben Ghezala; Déa Haddad; Julie Blanc; Cyril Meillon; Rachid Madkouri; François Borsotti; Alain M Bron; Catherine Creuzot-Garcher

doi:10.1155/2021/5531959

Peripapillary Microvascularization Analysis Using Swept-Source Optical Coherence Tomography Angiography in Optic Chiasmal Compression

J Ophthalmol. 2021 Sep 4:2021:5531959. doi: 10.1155/2021/5531959. eCollection 2021.

Authors

Inès Ben Ghezala¹, Déa Haddad¹, Julie Blanc¹, Cyril Meillon¹, Rachid Madkouri², François Borsotti², Alain M Bron^{1

3}, Catherine Creuzot-Garcher^{1

3}

Affiliations

¹ Department of Ophthalmology, University Hospital, Dijon, France.
² Department of Neurosurgery, University Hospital, Dijon, France.
³ Taste and Food Science Centre, AgroSup Dijon, CNRS, INRAE, Bourgogne Franche-Comté University, F-21000 Dijon, France.

Abstract

Purpose: To evaluate the vessel density (VD) of the radial peripapillary capillary (RPC) network using swept-source optical coherence tomography angiography (SS-OCTA) "en face" images of eyes with chiasmal compression caused by brain tumors before and after decompressive surgery compared with healthy controls.

Methods: A cross-sectional study was conducted in 12 patients with chiasmal compression confirmed by neuroimaging. Sixteen healthy participants were also included. All patients with chiasmal compression underwent a neuro-ophthalmological examination one week before and 6 months after brain surgery, including static automated perimetry as well as measurement of the thickness of the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) with spectral-domain optical coherence tomography (SD-OCT). Based on this neuro-ophthalmological examination, the presence of an optic neuropathy (ON) was evaluated. Peripapillary VD was obtained in four sectors on a 6 × 6 mm SS-OCTA image using the Cirrus Plex Elite 9000.

Results: Baseline average VD was significantly lower in patients with chiasmal compression and ON than in controls (median: 55.62; interquartile range (IQR): 2.96 vs. 58.53; IQR: 2.02; p=0.003). This decrease was also found in the temporal, superior, and nasal sectors. Average postoperative VD was decreased in patients with chiasmal compression compared with average preoperative VD (median: 56.16; IQR: 4.07 vs. 57.48; IQR: 3.83; p=0.004). Preoperative VD was significantly correlated with RNFL, GCC thickness, and visual field defects.

Conclusions: The VD of the RPC network was decreased in chiasmal compressive ON, and it was further decreased at 6 months after decompressive surgery.