Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

Eur J Immunol. 2021 Dec;51(12):3243-3246. doi: 10.1002/eji.202149315. Epub 2021 Sep 28.

Abstract

Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.

Keywords: EOMES; IL-10R; Tr1-like cells; microRNAs.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Profiling*
  • Humans
  • MicroRNAs / immunology*
  • Receptors, Interleukin-10 / immunology*
  • T-Box Domain Proteins / immunology*
  • Th1 Cells / immunology*

Substances

  • EOMES protein, human
  • MIRN125 microRNA, human
  • MIRN92 microRNA, human
  • MicroRNAs
  • Receptors, Interleukin-10
  • T-Box Domain Proteins